Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 3/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 9/20 | 0.39 |
| ▸ | PPARA | Q07869 | 7/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606992 | 0.82 | P2RX3 (0.41) | FAAHMGLLCASP3DAGLAMEN1 | |
| SCHEMBL5613790 | 0.72 | P2RX3 (0.35) | FAAHMGLLCASP3DAGLAMEN1 | |
| SCHEMBL17844142 | 0.69 | GAA (0.38) | FAAHMGLLDAGLAPPARGPPARA | |
| SCHEMBL3488367 | 0.69 | KMT2A (0.44) | DAGLAPPARGPPARAKMT2A | |
| SCHEMBL5320278 | 0.66 | ALDH1A1 (0.49) | FAAHMGLLMEN1NPC1RAB9A | |
| SCHEMBL5607253 | 0.66 | MAPT (0.38) | FAAHMGLLMEN1KMT2A | |
| SCHEMBL25053686 | 0.65 | ERCC5 (0.75) | ERCC5FEN1 | |
| SCHEMBL3487425 | 0.65 | KMT2A (0.42) | DAGLAPPARGPPARAKMT2A | |
| SCHEMBL5606915 | 0.64 | ALDH1A1 (0.43) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7759036 | 0.64 | DRD1 (0.59) | DAGLAPPARGPPARAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |