Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 9/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613790 | 0.89 | P2RX3 (0.35) | P2RX3MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL5607253 | 0.84 | MAPT (0.38) | P2RX3MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL5655941 | 0.82 | FAAH (0.42) | MEN1KMT2AFAAHMGLLCASP3 | |
| SCHEMBL5606915 | 0.82 | ALDH1A1 (0.43) | P2RX3MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL5614183 | 0.76 | P2RX3 (0.37) | P2RX3ALDH1A1KMT2AGAADAGLA | |
| SCHEMBL17844142 | 0.74 | GAA (0.38) | MAPTALDH1A1FAAHMGLLGAA | |
| SCHEMBL3487222 | 0.70 | NR1H2 (0.44) | P2RX3MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL5606522 | 0.69 | PLK1 (0.41) | MAPTMEN1ALDH1A1KMT2AFAAH | |
| SCHEMBL5606238 | 0.68 | PGR (0.38) | P2RX3MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL3488264 | 0.67 | NR1H2 (0.53) | MAPTMEN1KMT2ACASP3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |