Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039696 | 0.94 | CA12 (0.35) | — | |
| SCHEMBL419996 | 0.94 | — | — | |
| Potassium Ion SCHEMBL11855148 | 0.73 | — | — | |
| SCHEMBL11309327 | 0.71 | TDP1 (0.40) | — | |
| SCHEMBL8513659 | 0.71 | — | — | |
| SCHEMBL35180 | 0.69 | — | — | |
| Potassium Ion SCHEMBL9851169 | 0.69 | CA12 (0.47) | — | |
| Potassium Ion SCHEMBL9788101 | 0.69 | CA12 (0.47) | — | |
| SCHEMBL11227209 | 0.69 | NOS3 (0.42) | — | |
| Potassium Ion SCHEMBL9181470 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220041782-A1 | PRACTICAL SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-02-10 | — | — | US | claimed |
| US-20180171055-A1 | SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-06-21 | — | — | US | claimed |
| WO-2017034660-A1 | SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-02 | — | — | WO | claimed |
| CN-115504979-A | Method for synthesizing mercaptopurine | 南京卡文迪许生物工程技术有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-109942596-B | Synthesis method of thiolactone | 上海理工大学 | 2022-04-29 | — | — | CN | disclosed |
| US-20220041782-A1 | PRACTICAL SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-02-10 | — | — | US | disclosed |
| US-11111330-B2 | Synthesis of multiphase self-healing polymers from commodity monomers | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-09-07 | — | — | US | disclosed |
| CN-111138471-A | Thioacid radical end-capped mercaptosilane coupling agent and synthesis method and application thereof | 怡维怡橡胶研究院有限公司 | 2020-05-12 | — | — | CN | disclosed |
| US-20180171055-A1 | SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-06-21 | — | — | US | disclosed |
| WO-2017034660-A1 | SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-02 | — | — | WO | disclosed |
| US-7176214-B2 | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-13 | — | — | US | disclosed |
| EP-0046363-B1 | PROCESS FOR THE PREPARATION OF 2-THIO PENEM DERIVATIVES AND INTERMEDIATES THEREFOR | BEECHAM GROUP PLC (GB) | 1984-11-14 | — | — | EP | disclosed |
| US-4447360-A | Intermediates for thia-aza compounds with a β-lactam ring | CIBA-GEIGY CORPORATION (US) | 1984-05-08 | — | — | US | disclosed |
| US-4331676-A | 2-PENEM COMPOUNDS UNSUBSTITUTED IN THE 6 POSITION | CIBA-GEIGY CORPORATION (US) | 1982-05-25 | — | — | US | disclosed |
| EP-0046363-A1 | Process for the preparation of 2-thio penem derivatives and intermediates therefor | BEECHAM GROUP PLC (GB) | 1982-02-24 | — | — | EP | disclosed |
| EP-0041768-A2 | Beta-lactam compounds, their preparation and use | BEECHAM GROUP PLC (GB) | 1981-12-16 | — | — | EP | disclosed |
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4081386-A | ANTIOXIDANTS | THE LUBRIZOL CORPORATION (US) | 1978-03-28 | — | — | US | disclosed |
| US-4039677-A | FUNGICIDES, BACTERICIDES, ANTIPROTOZOA AGENTS | SYNTEX (U.S.A.) INC. (US) | 1977-08-02 | — | — | US | disclosed |