Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | SLC8A1 | P32418 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664625 | 0.95 | ATP4A (0.36) | RAB9AATP4AATP4BLMNABRD4 | |
| SCHEMBL5661208 | 0.87 | ATP4A (0.34) | ATP4AATP4BSLC8A1 | |
| SCHEMBL4662876 | 0.86 | ATP4A (0.37) | RAB9AATP4AATP4BLMNASLC8A1 | |
| SCHEMBL4964853 | 0.84 | ADRA1A (0.31) | SLC8A1 | |
| SCHEMBL6020045 | 0.82 | DHODH (0.36) | RAB9AATP4AATP4BSLC8A1CYP19A1 | |
| SCHEMBL6019450 | 0.82 | DHODH (0.36) | RAB9AATP4AATP4BSLC8A1CYP19A1 | |
| SCHEMBL4663178 | 0.82 | DHODH (0.36) | RAB9AATP4AATP4BSLC8A1CYP19A1 | |
| SCHEMBL4664632 | 0.81 | ALDH1A1 (0.38) | ATP4AATP4BLMNASLC8A1ALDH1A1 | |
| SCHEMBL5506543 | 0.80 | RAB9A (0.35) | RAB9AATP4AATP4BSLC8A1CYP19A1 | |
| SCHEMBL4666543 | 0.80 | RAB9A (0.35) | RAB9AATP4AATP4BSLC8A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307084-B2 | Cyclic benzimidazoles | ALTANA PHARMA AG (DE) | 2007-12-11 | — | — | US | claimed |