Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9004471 | 0.85 | POLB (0.50) | POLBGAALMNAMAPTL3MBTL1 | |
| SCHEMBL7088667 | 0.83 | CA12 (0.49) | POLBGAALMNAMAPTL3MBTL1 | |
| SCHEMBL5754677 | 0.81 | KMT2A (0.55) | POLBGAALMNAMAPTL3MBTL1 | |
| SCHEMBL7160912 | 0.81 | POLB (0.68) | POLBLMNAMAPTALOX15ALDH1A1 | |
| SCHEMBL5665343 | 0.81 | POLB (0.46) | POLBGAAESR1LMNAMAPT | |
| SCHEMBL9004470 | 0.81 | POLB (0.46) | POLBGAALMNAMAPTL3MBTL1 | |
| SCHEMBL7828967 | 0.79 | POLB (0.44) | POLBGAALMNAMAPTL3MBTL1 | |
| SCHEMBL14029225 | 0.79 | KDM4E (0.44) | POLBGAALMNAMAPTL3MBTL1 | |
| SCHEMBL5664826 | 0.78 | POLB (0.44) | POLBGAAESR1LMNAMAPT | |
| SCHEMBL9004484 | 0.77 | POLB (0.43) | POLBGAALMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | TARGANTA THERAPEUTICA INC. (CA) | 2008-11-20 | — | — | US | disclosed |
| US-20060205692-A1 | 1,1-and 1,2-Bisphosphonates as apoliprotein e modulators | MONTES IMBER F | 2006-09-14 | — | — | US | disclosed |
| EP-1506208-A4 | 1,1- AND 1,2-BISPHOSPHONATES AS APOLIPOPROTEIN E MODULATORS | ILEX PRODUCTS INC (US) | 2006-05-24 | — | — | EP | disclosed |
| EP-1506208-A2 | 1,1- AND 1,2-BISPHOSPHONATES AS APOLIPOPROTEIN E MODULATORS | Ilex Products, Inc. (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003094851-A2 | 1,1- AND 1,2-BISPHOSPHONATES AS APOLIPROTEIN E MODULATORS | ILEX PRODUCTS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | BPGM, PSPH, PGLS | POLB 237/4885GAA 1879/4885ESR1 4466/4885 |
| US-20060205692-A1 | 1,1-and 1,2-Bisphosphonates as apoliprotein e modulators | APOB, APOL1, HDLBP | POLB 2990/4885GAA 1324/4885ESR1 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.