Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 7/20 | 0.35 |
| ▸ | NOS2 | P35228 | 5/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5666297 | 0.89 | KLKB1 (0.37) | CYP2C19CYP2D6KCNE1KCNA5MC4R | |
| SCHEMBL5664748 | 0.89 | BCHE (0.34) | PLAUNOS1NOS2USP30 | |
| SCHEMBL4986155 | 0.87 | PLAU (0.40) | PLAUNOS1NOS2CYP2C19MC4R | |
| SCHEMBL5667138 | 0.83 | ALOX12 (0.36) | PLAUTP53MAPT | |
| SCHEMBL5664871 | 0.80 | PLAU (0.38) | PLAUNOS1TECHDAC3 | |
| SCHEMBL5664741 | 0.79 | RAB9A (0.36) | — | |
| SCHEMBL4986144 | 0.77 | MEN1 (0.40) | CYP2C19MC4RMC3RMAPT | |
| SCHEMBL5664693 | 0.74 | PLAU (0.40) | PLAUNOS1NOS2 | |
| SCHEMBL5667134 | 0.73 | OPRM1 (0.40) | PLAUTP53MAPT | |
| SCHEMBL5009972 | 0.71 | PLAU (0.40) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |