Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664748 | 0.90 | BCHE (0.34) | RAB9ANPC1BCHEKDM4EALDH1A1 | |
| SCHEMBL5666297 | 0.89 | KLKB1 (0.37) | RAB9AKLKB1MAP4K1SCN7AKCNH2 | |
| SCHEMBL5667134 | 0.85 | OPRM1 (0.40) | KLKB1MAP4K1OPRM1TMEM97SIGMAR1 | |
| SCHEMBL4986144 | 0.78 | MEN1 (0.40) | RAB9ANPC1OPRM1TMEM97SIGMAR1 | |
| SCHEMBL5667138 | 0.76 | ALOX12 (0.36) | KDM4EALDH1A1POLB | |
| SCHEMBL5664213 | 0.75 | MTTP (0.47) | — | |
| SCHEMBL5664217 | 0.75 | MTTP (0.47) | — | |
| SCHEMBL5664692 | 0.74 | KLKB1 (0.38) | RAB9AKLKB1MAP4K1NPC1OPRM1 | |
| SCHEMBL5664866 | 0.73 | KLKB1 (0.40) | RAB9AKLKB1MAP4K1SCN7AKCNH2 | |
| SCHEMBL5669409 | 0.72 | KLKB1 (0.39) | KLKB1MAP4K1KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |