Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667138 | 0.91 | ALOX12 (0.36) | ALDH1A1L3MBTL1KMT2AALOX12TP53 | |
| SCHEMBL5664741 | 0.85 | RAB9A (0.36) | OPRM1TMEM97SIGMAR1KLKB1MAP4K1 | |
| SCHEMBL5669409 | 0.84 | KLKB1 (0.39) | KLKB1MAP4K1ALDH1A1KMT2AALOX12 | |
| SCHEMBL5666297 | 0.83 | KLKB1 (0.37) | OPRM1TMEM97SIGMAR1KLKB1MAP4K1 | |
| SCHEMBL5663596 | 0.77 | MTTP (0.43) | DRD3 | |
| SCHEMBL5663591 | 0.77 | MTTP (0.43) | DRD3 | |
| SCHEMBL5664748 | 0.76 | BCHE (0.34) | ALDH1A1PLAUKDM4ESMN1; SMN2POLB | |
| SCHEMBL4986144 | 0.74 | MEN1 (0.40) | OPRM1TMEM97SIGMAR1OPRK1L3MBTL1 | |
| SCHEMBL5669411 | 0.73 | TLR2 (0.39) | ALOX12ALOX15PLGPRSS1PRSS2 | |
| SCHEMBL5664866 | 0.71 | KLKB1 (0.40) | KLKB1MAP4K1ALDH1A1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |