Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 7/20 | 0.52 |
| ▸ | MAOB | P27338 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL510249 | 0.85 | ALDH1A1 (0.70) | TLR4TLR2MAOAMAOBSMN1; SMN2 | |
| SCHEMBL30777705 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL1299578 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL5543437 | 0.79 | MAOA (0.66) | TLR4TLR2MAOAMAOBSMN1; SMN2 | |
| SCHEMBL30791325 | 0.79 | MAOA (0.71) | TLR4TLR2MAOAMAOBKDM4E | |
| SCHEMBL923674 | 0.79 | MAOA (0.71) | TLR4TLR2MAOAMAOBKDM4E | |
| SCHEMBL9059700 | 0.78 | MAOA (0.70) | TLR4TLR2MAOAMAOBSMN1; SMN2 | |
| SCHEMBL10697786 | 0.78 | HRH1 (0.53) | SMN1; SMN2ALDH1A1HPGDRAB9ACA12 | |
| SCHEMBL30724528 | 0.78 | MAOA (0.64) | TLR4TLR2MAOAMAOBALDH1A1 | |
| SCHEMBL13645879 | 0.78 | TDP1 (0.60) | SMN1; SMN2KDM4EALDH1A1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060205692-A1 | 1,1-and 1,2-Bisphosphonates as apoliprotein e modulators | MONTES IMBER F | 2006-09-14 | — | — | US | disclosed |
| EP-1506208-A4 | 1,1- AND 1,2-BISPHOSPHONATES AS APOLIPOPROTEIN E MODULATORS | ILEX PRODUCTS INC (US) | 2006-05-24 | — | — | EP | disclosed |
| EP-1506208-A2 | 1,1- AND 1,2-BISPHOSPHONATES AS APOLIPOPROTEIN E MODULATORS | Ilex Products, Inc. (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003094851-A2 | 1,1- AND 1,2-BISPHOSPHONATES AS APOLIPROTEIN E MODULATORS | ILEX PRODUCTS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205692-A1 | 1,1-and 1,2-Bisphosphonates as apoliprotein e modulators | APOB, APOL1, HDLBP | TLR4 1874/4885TLR2 2349/4885MAOA 3449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.