Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 9/20 | 0.47 |
| ▸ | GART | P22102 | 5/20 | 0.47 |
| ▸ | ATIC | P31939 | 4/20 | 0.47 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29619286 | 1.00 | TYMS (0.66) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL8897352 | 0.93 | TYMS (0.80) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL16681740 | 0.89 | AKR1B1 (0.51) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL609951 | 0.85 | AKR1B1 (0.49) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL16058737 | 0.85 | AKR1B1 (0.49) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL17811602 | 0.83 | AKR1B1 (0.45) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL2906514 | 0.83 | TYMS (0.62) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27812907 | 0.82 | TYMS (0.62) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL7639622 | 0.81 | AKR1B1 (0.46) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL7522026 | 0.81 | TYMS (0.66) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137386-B8 | USE OF TRICLOSAN AS AN ANTIMALARIAL AGENT | JAWAHARLAL NEHRU CT FOR ADVANC (IN) | 2006-12-13 | — | — | EP | disclosed |
| EP-1137386-B1 | USE OF TRICLOSAN AS AN ANTIMALARIAL AGENT | JAWAHARLAL NEHRU CT FOR ADVANC (IN) | 2006-05-03 | — | — | EP | disclosed |
| EP-1137386-A2 | USE OF HYDROXYDIPHENYL ETHER AS AN ANTIMALARIAL AGENT | Jawaharlal Nehru Centre For Advanced Scientific Research (IN) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001000138-A2 | USE OF HYDROXYDIPHENYL ETHER CLASS OF CHEMICALS, AS EXEMPLIFIED BY TRICLOSAN, AS AN ANTIMALARIAL AND IDENTIFICATION OF FATTY ACID SYNTHESIS AS ITS TARGET | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2001-01-04 | — | — | WO | disclosed |