Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 3/20 | 0.47 |
| ▸ | GART | P22102 | 3/20 | 0.47 |
| ▸ | ATIC | P31939 | 1/20 | 0.47 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.46 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.44 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrofolic Acid SCHEMBL7004617 | 0.94 | TYMS (0.59) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL1880562 | 0.92 | TYMS (0.78) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL8897352 | 0.87 | TYMS (0.80) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL8281 | 0.83 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL8282 | 0.83 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL12136386 | 0.83 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL38662929 | 0.83 | TYMS (0.97) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL27589172 | 0.83 | SOST (0.61) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Dihydrofolic Acid SCHEMBL27415499 | 0.82 | SOST (0.60) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL7526552 | 0.81 | GART (0.44) | DHFRGARTATICSOSTMTHFD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178052-A2 | Genes identified as required for proliferation in Escherichia coli | Elitra Pharmaceuticals, Inc. (US) | 2002-02-06 | — | — | EP | disclosed |