Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167070 | 0.80 | MEN1 (0.49) | HDAC1HDAC2LMNAROCK2ALDH1A1 | |
| SCHEMBL31420663 | 0.73 | PLAU (0.46) | ROCK2 | |
| SCHEMBL9158553 | 0.71 | NR4A2 (0.63) | BRD4HDAC1HDAC2LMNAALDH1A1 | |
| SCHEMBL23940250 | 0.71 | BRD4 (0.71) | BRD4HDAC1HDAC2LMNABCHE | |
| SCHEMBL27249468 | 0.69 | KDM4E (0.61) | BRD4LMNAALDH1A1KMT2A | |
| SCHEMBL1093252 | 0.69 | BRD4 (0.69) | BRD4HDAC1HDAC2LMNAALDH1A1 | |
| SCHEMBL7364339 | 0.69 | HTR3A (0.67) | BRD4HDAC1HDAC2LMNAALDH1A1 | |
| SCHEMBL29846680 | 0.69 | HDAC1 (0.48) | BRD4HDAC1HDAC2LMNABCHE | |
| SCHEMBL16644162 | 0.69 | TP53 (0.72) | ALDH1A1TP53THRBMAPTKMT2A | |
| SCHEMBL28968558 | 0.69 | HDAC1 (0.58) | BRD4HDAC1HDAC2LMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | MSD K.K. (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | HTR1F, HTR3C, HTR6 | BRD4 110/4885HDAC1 708/4885HDAC2 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.