Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5668616 | 0.90 | NEK2 (0.49) | ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL5666160 | 0.89 | TSHR (0.49) | LMNAALDH1A1PKMMEN1KMT2A | |
| SCHEMBL5668628 | 0.86 | SMN1; SMN2 (0.41) | LMNAALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL5666460 | 0.82 | ALDH1A1 (0.54) | LMNAALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL3915181 | 0.81 | LMNA (0.55) | LMNAALDH1A1HSD11B1PKMNR3C1 | |
| SCHEMBL5666899 | 0.80 | SMN1; SMN2 (0.51) | LMNAALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL4035567 | 0.79 | LMNA (0.48) | LMNAALDH1A1HSD11B1PKMNR3C1 | |
| SCHEMBL5668378 | 0.78 | ALDH1A1 (0.57) | LMNAALDH1A1PKMNPC1RAB9A | |
| SCHEMBL5666119 | 0.77 | SMN1; SMN2 (0.39) | LMNAPKMNPC1HTT | |
| SCHEMBL3917062 | 0.77 | CHRM5 (0.46) | LMNAALDH1A1HSD11B1PKMNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5|DECAN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005095398-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | disclosed |