Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927380 | 0.91 | CYP2D6 (0.45) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL3915181 | 0.90 | LMNA (0.55) | LMNAPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL4034055 | 0.90 | L3MBTL1 (0.45) | LMNAPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL4037894 | 0.89 | ALDH1A1 (0.54) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL4041277 | 0.88 | KMT2A (0.41) | LMNAMEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL4032408 | 0.84 | ALDH1A1 (0.52) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3917062 | 0.83 | CHRM5 (0.46) | LMNAPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL4041475 | 0.83 | MMP2 (0.39) | LMNAMEN1KMT2AALDH1A1GAA | |
| SCHEMBL2942516 | 0.83 | SMN1; SMN2 (0.48) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4041453 | 0.82 | MEN1 (0.42) | LMNAMEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |