Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760449 | 0.80 | NPSR1 (0.59) | MAPTRAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL27719797 | 0.79 | RAB9A (0.55) | MAPTRAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL28111104 | 0.77 | L3MBTL1 (0.47) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL2559709 | 0.75 | ALDH1A1 (0.50) | ALDH1A1TDP1TSHRHPGD | |
| SCHEMBL5476076 | 0.74 | ALDH1A1 (0.31) | MAPTNPSR1ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL19888140 | 0.74 | CA1 (0.57) | MAPTKMT2ANPSR1HDAC1MAPK1 | |
| SCHEMBL3004700 | 0.72 | GAA (0.49) | MAPTMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL19888143 | 0.70 | LMNA (0.63) | MAPTRAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL2717803 | 0.69 | ALDH1A1 (0.46) | MAPTRAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL14163841 | 0.69 | TSHR (0.52) | MAPTRAB9AHDAC1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729755-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005070407-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | disclosed |