Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MYC | P01106 | 3/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777522 | 0.79 | NOS3 (0.41) | KDM4EMYCALDH1A1L3MBTL1GAA | |
| SCHEMBL18586369 | 0.77 | KDM4E (0.47) | KDM4EMYCNR4A1ALDH1A1L3MBTL1 | |
| SCHEMBL29232582 | 0.76 | KDM4E (0.33) | KDM4EMYCNR4A1ALDH1A1L3MBTL1 | |
| SCHEMBL2773550 | 0.76 | MYC (0.32) | KDM4EMYCALDH1A1L3MBTL1GAA | |
| SCHEMBL5777870 | 0.73 | GRIN2D (0.41) | KDM4EMYCNR4A1ALDH1A1L3MBTL1 | |
| SCHEMBL17708596 | 0.73 | NOS1 (0.47) | — | |
| SCHEMBL8326929 | 0.73 | NOS2 (0.48) | KDM4EALDH1A1L3MBTL1GAAHPGD | |
| SCHEMBL8331278 | 0.73 | NOS3 (0.48) | KDM4EALDH1A1L3MBTL1GAAHPGD | |
| SCHEMBL1821173 | 0.72 | — | — | |
| SCHEMBL5930607 | 0.72 | ALDH1A1 (0.40) | KDM4EMYCNR4A1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331910-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | UNIV NORTHWESTERN (US) | 2020-10-22 | — | — | US | disclosed |
| US-10759791-B2 | Mammalian and bacterial nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2020-09-01 | — | — | US | disclosed |
| US-9951014-B2 | Mammalian and bacterial nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951014-B2 | Mammalian and bacterial nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-09-28 | — | — | US | disclosed |
| EP-3215497-A2 | MAMMALIAN AND BACTERIAL NITRIC OXIDE SYNTHASE INHIBITORS | Northwestern University (US) | 2017-09-13 | — | — | EP | disclosed |
| WO-2016073623-A2 | MAMMALIAN AND BACTERIAL NITRIC OXIDE SYNTHASE INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2016-05-12 | — | — | WO | disclosed |
| WO-2016073623-A2 | MAMMALIAN AND BACTERIAL NITRIC OXIDE SYNTHASE INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2016-05-12 | — | — | WO | disclosed |
| US-20160122302-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-05-05 | — | — | US | disclosed |
| US-20160122302-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-05-05 | — | — | US | disclosed |
| US-20160122302-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-05-05 | — | — | US | disclosed |
| US-20060194847-A1 | Novel 6-substituted 2-aminopyridine derivatives | ASTRAZENECA AB (SE) | 2006-08-31 | — | — | US | disclosed |
| EP-1611099-A1 | NOVEL 6-SUBSTITUTED 2-AMINOPYRIDINE DERIVATIVES | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004087665-A1 | NOVEL 6-SUBSTITUTED 2-AMINOPYRIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331910-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NOS1, NOS2, NOS3 | KDM4E 3861/4885MYC 2236/4885NR4A1 3304/4885 |
| US-20160122302-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NOS1, NOS2, NOS3 | KDM4E 2967/4885MYC 2576/4885NR4A1 3804/4885 |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NOS1, NOS2, NOS3 | KDM4E 3861/4885MYC 2236/4885NR4A1 3304/4885 |
| US-10759791-B2 | Mammalian and bacterial nitric oxide synthase inhibitors | NOS1, NOS2, NOS3 | KDM4E 3861/4885MYC 2236/4885NR4A1 3304/4885 |
| US-20060194847-A1 | Novel 6-substituted 2-aminopyridine derivatives | NOS1, NOS2, NOS3 | KDM4E 1914/4885MYC 4713/4885NR4A1 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.