Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.53 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28868864 | 0.82 | LOXL2 (0.50) | CRHBPCRHR2PYCR1LOXL2IDO1 | |
| SCHEMBL4810294 | 0.81 | CRHBP (0.61) | CRHBPCRHR2PYCR1LOXL2FAAH | |
| SCHEMBL19760403 | 0.80 | CRHBP (0.55) | CRHBPCRHR2PYCR1LOXL2ALDH1A1 | |
| SCHEMBL1938688 | 0.78 | IDO1 (0.49) | CRHBPCRHR2PYCR1LOXL2IDO1 | |
| SCHEMBL3153458 | 0.77 | CRHBP (0.64) | CRHBPCRHR2PYCR1LOXL2IDO1 | |
| SCHEMBL5655968 | 0.77 | ALDH1A1 (0.47) | CRHBPCRHR2PYCR1FAAHMGLL | |
| Hydrochloric Acid SCHEMBL1937677 | 0.77 | IDO1 (0.50) | CRHBPCRHR2PYCR1LOXL2IDO1 | |
| SCHEMBL3161509 | 0.76 | PYCR1 (0.57) | CRHBPCRHR2PYCR1LOXL2IDO1 | |
| SCHEMBL8790300 | 0.76 | CRHBP (0.51) | CRHBPCRHR2PYCR1LOXL2ALDH1A1 | |
| SCHEMBL27890501 | 0.76 | CRHBP (0.58) | CRHBPCRHR2ALDH1A1CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658265-A4 | 4-(METHYL SULFONYL AMINO) PHENYL ANALOGUES AS VANILLOID ANTAGONIST SHOWING EXCELLENT ANALGESIC ACTIVITY AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | GRUENENTHAL GMBH (DE) | 2006-11-29 | — | — | EP | disclosed |
| EP-1658265-A1 | 4-(METHYL SULFONYL AMINO) PHENYL ANALOGUES AS VANILLOID ANTAGONIST SHOWING EXCELLENT ANALGESIC ACTIVITY AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | Grünenthal GmbH (DE) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005003084-A1 | 4-(METHYL SULFONYL AMINO) PHENYL ANALOGUES AS VANILLOID ANTAGONIST SHOWING EXCELLENT ANALGESIC ACTIVITY AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | GRUNENTHAL GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |