Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5677341 | 0.99 | OPRK1 (0.46) | OPRD1OPRK1ALDH1A1SMN1; SMN2GRIN2D | |
| Hydrochloric Acid SCHEMBL27582452 | 0.85 | OPRD1 (0.49) | OPRD1OPRK1ALDH1A1SMN1; SMN2SLC6A2 | |
| SCHEMBL5674046 | 0.82 | SLC6A2 (0.49) | OPRD1OPRK1ALDH1A1SMN1; SMN2GRIN2D | |
| SCHEMBL5675100 | 0.81 | OPRK1 (0.62) | OPRD1OPRK1SLC6A2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL5677586 | 0.81 | OPRM1 (0.50) | OPRD1OPRK1ALDH1A1SMN1; SMN2GRIN2D | |
| SCHEMBL5673865 | 0.80 | SMN1; SMN2 (0.57) | OPRD1OPRK1SMN1; SMN2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5677175 | 0.80 | OPRK1 (0.62) | OPRD1OPRK1SLC6A2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL5677140 | 0.80 | SMN1; SMN2 (0.59) | OPRD1OPRK1ALDH1A1SMN1; SMN2SLC6A2 | |
| SCHEMBL5673834 | 0.79 | SLC6A2 (0.46) | OPRD1OPRK1ALDH1A1SMN1; SMN2GRIN2D | |
| SCHEMBL5675035 | 0.79 | OPRD1 (0.68) | OPRD1OPRK1SLC6A2SLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049327-B2 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1370529-B1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-01-11 | — | — | EP | claimed |
| US-20040127516-A1 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2004-07-01 | — | — | US | claimed |
| CN-1496352-A | Substituted dimethyl- [ 1- (1-phenyl-cyclohexyl) -piperidin-3-ylmethyl ] -amines and their use as analgesics | — | 2004-05-12 | — | — | CN | claimed |
| EP-1370529-A1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2003-12-17 | — | — | EP | claimed |
| WO-2002072550-A1 | SUBSTITUTED DIMETHYL-[1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2002-09-19 | — | — | WO | claimed |
| US-7049327-B2 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2006-05-23 | — | — | US | disclosed |
| EP-1370529-B1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-20040127516-A1 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2004-07-01 | — | — | US | disclosed |
| CN-1496352-A | Substituted dimethyl- [ 1- (1-phenyl-cyclohexyl) -piperidin-3-ylmethyl ] -amines and their use as analgesics | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1370529-A1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002072550-A1 | SUBSTITUTED DIMETHYL-[1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127516-A1 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | OPRM1, OPRK1, PNMT | OPRD1 6/4885OPRK1 2/4885ALDH1A1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.