Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 19/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 17/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5677175 | 0.99 | OPRK1 (0.62) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| SCHEMBL5673865 | 0.89 | SMN1; SMN2 (0.57) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5677140 | 0.88 | SMN1; SMN2 (0.59) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| SCHEMBL5675035 | 0.87 | OPRD1 (0.68) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5675172 | 0.86 | OPRD1 (0.67) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| SCHEMBL5674046 | 0.82 | SLC6A2 (0.49) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| SCHEMBL5675079 | 0.81 | OPRD1 (0.46) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5677586 | 0.81 | OPRM1 (0.50) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5677341 | 0.80 | OPRK1 (0.46) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 | |
| SCHEMBL28052127 | 0.80 | OPRK1 (0.69) | OPRK1OPRD1OPRM1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049327-B2 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1370529-B1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-01-11 | — | — | EP | claimed |
| US-20040127516-A1 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2004-07-01 | — | — | US | claimed |
| CN-1496352-A | Substituted dimethyl- [ 1- (1-phenyl-cyclohexyl) -piperidin-3-ylmethyl ] -amines and their use as analgesics | — | 2004-05-12 | — | — | CN | claimed |
| EP-1370529-A1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2003-12-17 | — | — | EP | claimed |
| WO-2002072550-A1 | SUBSTITUTED DIMETHYL-[1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2002-09-19 | — | — | WO | claimed |
| US-7049327-B2 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2006-05-23 | — | — | US | disclosed |
| EP-1370529-B1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-20040127516-A1 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | GRUENENTHAL GMBH (DE) | 2004-07-01 | — | — | US | disclosed |
| CN-1496352-A | Substituted dimethyl- [ 1- (1-phenyl-cyclohexyl) -piperidin-3-ylmethyl ] -amines and their use as analgesics | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1370529-A1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002072550-A1 | SUBSTITUTED DIMETHYL-[1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127516-A1 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amines and the use of the same as analgesics | OPRM1, OPRK1, PNMT | OPRK1 2/4885OPRD1 6/4885OPRM1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.