Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.38 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.36 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215839 | 0.85 | VDR (0.38) | VDRAGTR1AGTR2GP6 | |
| SCHEMBL5672551 | 0.85 | VDR (0.39) | VDRTRAP1HSP90B1HSP90AA1PYCR1 | |
| SCHEMBL5673970 | 0.84 | TBXA2R (0.36) | AGTR1AGTR2TRAP1HSP90B1 | |
| SCHEMBL5673977 | 0.84 | TBXA2R (0.36) | AGTR1AGTR2TRAP1HSP90B1 | |
| SCHEMBL5675559 | 0.79 | AGTR1 (0.40) | AGTR1AGTR2GP6 | |
| SCHEMBL5174047 | 0.79 | VDR (0.41) | VDRTRAP1HSP90B1 | |
| SCHEMBL5672575 | 0.78 | VDR (0.39) | VDRTRAP1HSP90B1HSP90AA1PYCR1 | |
| SCHEMBL28515127 | 0.76 | AGTR1 (0.52) | VDRAGTR1AGTR2GP6 | |
| SCHEMBL5673975 | 0.74 | P2RX3 (0.35) | AGTR1AGTR2 | |
| SCHEMBL5675471 | 0.73 | HDAC8 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060721-B1 | Imidazole compounds and medicinal use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2006-06-13 | — | — | US | disclosed |
| EP-1142879-A1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |