Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.41 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679215 | 0.84 | HDAC8 (0.53) | HDAC8MTNR1AMTNR1BACHECA1 | |
| SCHEMBL5681677 | 0.84 | MTNR1A (0.53) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL7035289 | 0.84 | MTNR1A (0.53) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL5679130 | 0.83 | MTNR1A (0.52) | HDAC8MTNR1AMTNR1BACHECA1 | |
| SCHEMBL9443701 | 0.82 | ADRB3 (0.51) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL9443694 | 0.82 | ADRB3 (0.51) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL9443665 | 0.82 | ADRB3 (0.51) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL5681735 | 0.82 | ACHE (0.48) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL5681712 | 0.81 | ACHE (0.53) | HDAC8MTNR1AMTNR1BACHEDRD2 | |
| Hydrochloric Acid SCHEMBL5677460 | 0.80 | ACHE (0.52) | HDAC8MTNR1AMTNR1BACHEDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030160-B2 | Propanolaminotetralines, preparation thereof and compositions containing same | SANOFI-AVENTIS (FR) | 2006-04-18 | — | — | US | disclosed |
| US-20040034070-A1 | Propanolaminotetralines, preparation thereof and compositions containing same | SANOFI-AVENTIS (FR) | 2004-02-19 | — | — | US | disclosed |
| EP-1292572-B1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-02-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034070-A1 | Propanolaminotetralines, preparation thereof and compositions containing same | ADRB3, ADRB1, ADRB2 | HDAC8 4497/4885MTNR1A 627/4885MTNR1B 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.