Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679610 | 0.83 | TRPA1 (0.58) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL5680411 | 0.81 | TRPA1 (0.52) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| Hydrochloric Acid SCHEMBL27141683 | 0.80 | DHFR (0.47) | DHFRMAP4K4PIK3R1PIK3CATNKS2 | |
| Hydrochloric Acid SCHEMBL30034451 | 0.80 | DHFR (0.47) | DHFRMAP4K4PIK3R1PIK3CATNKS2 | |
| SCHEMBL5679139 | 0.78 | ALDH1A1 (0.50) | DHFRALDH1A1MEN1KMT2AMASP2 | |
| SCHEMBL5682985 | 0.78 | BACE1 (0.52) | MAP4K4PIK3R1PIK3CATNKS2ALDH1A1 | |
| SCHEMBL5678732 | 0.78 | JAK2 (0.55) | TNKS2ALDH1A1MEN1KMT2AMASP2 | |
| SCHEMBL5683290 | 0.77 | ALDH1A1 (0.48) | MAP4K4ALDH1A1MEN1KMT2AMASP2 | |
| SCHEMBL5679580 | 0.76 | MAP4K4 (0.49) | MAP4K4ALDH1A1MEN1KMT2AMASP2 | |
| SCHEMBL3827667 | 0.76 | ALDH1A1 (0.58) | DHFRPIK3CAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620413-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098494-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |