Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 14/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679161 | 0.83 | DHFR (0.56) | ALOX5APFEN1ABL1NPSR1MASP2 | |
| SCHEMBL2359317 | 0.82 | TRPA1 (0.56) | TRPA1ALOX5APFEN1ABL1SCN9A | |
| SCHEMBL5680087 | 0.79 | TYMS (0.44) | SCN9AMASP2MEN1ALDH1A1NUDT1 | |
| SCHEMBL5682985 | 0.78 | BACE1 (0.52) | TRPA1ALOX5APFEN1MASP2MEN1 | |
| SCHEMBL5680030 | 0.78 | XDH (0.58) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| Bromide SCHEMBL2380560 | 0.77 | XDH (0.57) | MASP2MEN1ALDH1A1NUDT1KMT2A | |
| SCHEMBL30026257 | 0.76 | TRPA1 (0.57) | TRPA1ALOX5APFEN1ABL1SCN9A | |
| SCHEMBL1798963 | 0.76 | TRPV1 (0.57) | TRPA1 | |
| SCHEMBL3745835 | 0.76 | CYP3A4 (0.62) | TRPA1ABL1SCN9APOLBNPSR1 | |
| SCHEMBL2770465 | 0.76 | CYP3A4 (0.62) | TRPA1ABL1SCN9APOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620413-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098494-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |