Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.47 |
| ▸ | FEN1 | P39748 | 2/20 | 0.47 |
| ▸ | QPCT | Q16769 | 2/20 | 0.45 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13373325 | 0.82 | IDO1 (0.49) | ALOX5APFEN1QPCTQPCTLCYP3A4 | |
| SCHEMBL30026100 | 0.81 | ALOX5AP (0.47) | TRPA1ALOX5APFEN1QPCTQPCTL | |
| SCHEMBL30025849 | 0.79 | QPCT (0.43) | TRPA1SCN9AALOX5APFEN1QPCT | |
| SCHEMBL13373341 | 0.77 | QPCT (0.51) | TRPA1ALOX5APFEN1QPCTQPCTL | |
| SCHEMBL5679610 | 0.76 | TRPA1 (0.58) | TRPA1SCN9AALOX5APFEN1ABL1 | |
| SCHEMBL27114186 | 0.75 | SMO (0.45) | QPCTABL1 | |
| SCHEMBL2359317 | 0.74 | TRPA1 (0.56) | TRPA1SCN9AALOX5APFEN1ABL1 | |
| SCHEMBL15916398 | 0.74 | ALOX5AP (0.83) | ALOX5APFEN1 | |
| SCHEMBL30026126 | 0.74 | QPCTL (0.51) | TRPA1ALOX5APFEN1QPCTQPCTL | |
| SCHEMBL13373350 | 0.74 | QPCT (0.51) | TRPA1ALOX5APFEN1QPCTQPCTL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187684-B2 | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORγ) and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2025-01-07 | — | — | US | disclosed |
| US-20230130361-A1 | Benzimidazole Derivatives as Modulators of Retinoid-Related Orphan Receptor Gamma (RORy) and Pharmaceutical Use Thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2023-04-27 | — | — | US | disclosed |
| US-11512055-B2 | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORγ) and pharmaceutical uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2022-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11512055-B2 | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORγ) and pharmaceutical uses thereof | RORC, RORB, RORA | TRPA1 1782/4885SCN9A 1601/4885ALOX5AP 3412/4885 |
| US-12187684-B2 | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORγ) and pharmaceutical use thereof | RORC, RORB, RORA | TRPA1 1700/4885SCN9A 1510/4885ALOX5AP 3450/4885 |
| US-20230130361-A1 | Benzimidazole Derivatives as Modulators of Retinoid-Related Orphan Receptor Gamma (RORy) and Pharmaceutical Use Thereof | RORB, RORA, RORC | TRPA1 1704/4885SCN9A 1577/4885ALOX5AP 3678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.