Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682947 | 0.87 | CCR2 (0.57) | CCR2ABCB11MAPTPKMKDM4E | |
| SCHEMBL5681979 | 0.84 | CCR2 (0.43) | CCR2ABCB11MAPTF10ALDH1A1 | |
| SCHEMBL5679174 | 0.83 | CCR2 (0.65) | CCR2ABCB11F10 | |
| SCHEMBL5679149 | 0.78 | CCR2 (0.54) | CCR2ABCB11KDM4EALDH1A1THRB | |
| SCHEMBL5680846 | 0.78 | CCR2 (0.54) | CCR2ABCB11 | |
| SCHEMBL5680853 | 0.76 | CCR2 (0.51) | CCR2ABCB11 | |
| SCHEMBL5683030 | 0.75 | CCR2 (0.53) | CCR2ABCB11F10 | |
| SCHEMBL5681505 | 0.75 | CCR2 (0.53) | CCR2ABCB11KDM4EALDH1A1 | |
| SCHEMBL7079549 | 0.73 | ABCB11 (0.54) | CCR2ABCB11MAPTGAALMNA | |
| SCHEMBL7072404 | 0.71 | CCR2 (0.67) | CCR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268423-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-03-01 | — | — | EP | claimed |