Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5680846 | 0.92 | CCR2 (0.54) | CCR2ABCB11 | |
| SCHEMBL5682947 | 0.87 | CCR2 (0.57) | CCR2ABCB11KDM4EALDH1A1 | |
| SCHEMBL5680853 | 0.87 | CCR2 (0.51) | CCR2ABCB11 | |
| SCHEMBL5679145 | 0.85 | CCR2 (0.75) | CCR2ABCB11 | |
| SCHEMBL5683030 | 0.80 | CCR2 (0.53) | CCR2ABCB11 | |
| SCHEMBL5681505 | 0.80 | CCR2 (0.53) | CCR2ABCB11KDM4EALDH1A1 | |
| SCHEMBL5679166 | 0.79 | CCR2 (0.57) | CCR2ABCB11KDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL7072404 | 0.78 | CCR2 (0.67) | CCR2ABCB11 | |
| SCHEMBL5679203 | 0.78 | CCR2 (0.45) | CCR2ABCB11KDM4EALDH1A1THRB | |
| SCHEMBL7079549 | 0.78 | ABCB11 (0.54) | CCR2ABCB11SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268423-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-03-01 | — | — | EP | claimed |