Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSH | P09668 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CASP14 | P31944 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017383 | 0.81 | MAPT (0.71) | MAPTLMNAKMT2AMEN1ALOX15 | |
| SCHEMBL16539318 | 0.80 | MAOB (0.47) | MAPTLMNAKMT2ACTSVPLAT | |
| SCHEMBL8006281 | 0.77 | MAPT (0.60) | MAPTLMNAKMT2AMEN1HSD17B10 | |
| SCHEMBL29152767 | 0.75 | MEN1 (0.51) | MAPTLMNAKMT2AMEN1 | |
| SCHEMBL30733200 | 0.75 | MEN1 (0.51) | MAPTLMNAKMT2AMEN1 | |
| SCHEMBL8022779 | 0.72 | MAPT (0.50) | MAPTLMNAKMT2AMEN1HSD17B10 | |
| SCHEMBL16539760 | 0.72 | GRM5 (0.50) | MAPTLMNAKMT2AMEN1TSHR | |
| SCHEMBL8015461 | 0.71 | LMNA (0.57) | MAPTLMNACTSVPLATCTSL | |
| SCHEMBL8006080 | 0.71 | LMNA (0.57) | MAPTLMNATSHRSMN1; SMN2TDP1 | |
| SCHEMBL8017798 | 0.71 | MAPT (0.71) | MAPTLMNAKMT2ACTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877735-B1 | POLYCYCLIC COMPOUNDS | UNIV STRATHCLYDE (GB) | 2006-03-08 | — | — | EP | disclosed |
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |