Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSZ | Q9UBR2 | 3/20 | 0.40 |
| ▸ | CTSV | O60911 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSH | P09668 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CASP4 | P49662 | 2/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | CASP14 | P31944 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017798 | 0.83 | MAPT (0.71) | LMNAMAPTCTSLCTSSCTSB | |
| SCHEMBL8015744 | 0.79 | MAPT (0.66) | LMNAMAPTCTSLCTSSCTSB | |
| SCHEMBL8006080 | 0.79 | LMNA (0.57) | LMNAMAPTALDH1A1POLBTDP1 | |
| SCHEMBL8006281 | 0.79 | MAPT (0.60) | LMNAMAPTALDH1A1POLBTDP1 | |
| SCHEMBL8019313 | 0.74 | MAPT (0.48) | LMNAMAPTALDH1A1POLBTDP1 | |
| SCHEMBL8017383 | 0.72 | MAPT (0.71) | LMNAMAPTGRM5ALDH1A1POLB | |
| SCHEMBL5682845 | 0.71 | MAPT (0.55) | LMNAMAPTCTSLCTSSCTSZ | |
| SCHEMBL8022790 | 0.70 | LMNA (0.50) | LMNAMAPTALDH1A1POLBTDP1 | |
| SCHEMBL5929653 | 0.65 | — | — | |
| SCHEMBL392912 | 0.65 | RAPGEF4 (0.54) | RAB9APAX8RAPGEF4EPAS1SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |