Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017798 | 0.83 | MAPT (0.71) | MAPTLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL5682845 | 0.81 | MAPT (0.55) | MAPTLMNAALOX15TSHRALDH1A1 | |
| SCHEMBL8015744 | 0.79 | MAPT (0.66) | MAPTLMNAHTTALDH1A1MAPK1 | |
| SCHEMBL8006281 | 0.79 | MAPT (0.60) | MAPTLMNAMAP2K1HTTALDH1A1 | |
| SCHEMBL29152727 | 0.76 | LMNA (0.42) | MAPTLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL8022779 | 0.73 | MAPT (0.50) | MAPTLMNATSHRALDH1A1CYP1A2 | |
| SCHEMBL17339198 | 0.73 | LMNA (0.40) | MAPTLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL8006080 | 0.72 | LMNA (0.57) | MAPTLMNAHTTTSHRALDH1A1 | |
| SCHEMBL8015461 | 0.72 | LMNA (0.57) | MAPTLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL8015467 | 0.67 | LMNA (0.50) | MAPTLMNAHTTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |
| EP-0877735-A1 | POLYCYCLIC COMPOUNDS | University of Strathclyde (GB) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997019929-A1 | POLYCYCLIC COMPOUNDS | THE UNIVERSITY OF STRATHCLYDE (GB) | 1997-06-05 | — | — | WO | disclosed |