Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | BUB1 | O43683 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017798 | 0.82 | MAPT (0.71) | MAPTLMNAHPGDMAPK1HTT | |
| SCHEMBL8015461 | 0.79 | LMNA (0.57) | MAPTLMNAMAPK1HTTRAPGEF4 | |
| SCHEMBL8017383 | 0.79 | MAPT (0.71) | MAPTLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL8015744 | 0.79 | MAPT (0.66) | MAPTLMNAHPGDMAPK1HTT | |
| SCHEMBL5682845 | 0.77 | MAPT (0.55) | MAPTLMNAHPGDSMN1; SMN2EGFR | |
| SCHEMBL8019313 | 0.74 | MAPT (0.48) | MAPTLMNAHPGDMAPK1HTT | |
| SCHEMBL8022790 | 0.73 | LMNA (0.50) | MAPTLMNAHPGDMAPK1HTT | |
| SCHEMBL8006080 | 0.72 | LMNA (0.57) | MAPTLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2119807 | 0.69 | SOS1 (0.61) | MAPTHPGDRAPGEF4IDO1SOS1 | |
| SCHEMBL8019487 | 0.65 | MAPT (0.48) | MAPTLMNAMAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |