Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | MMP9 | P14780 | 5/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.41 |
| ▸ | MMP14 | P50281 | 4/20 | 0.41 |
| ▸ | RORC | P51449 | 8/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17761315 | 0.68 | SLC6A3 (0.62) | RORC | |
| SCHEMBL2170203 | 0.66 | PARP1 (0.41) | — | |
| SCHEMBL17761293 | 0.66 | SLC6A3 (0.58) | — | |
| SCHEMBL1464260 | 0.66 | MMP2 (0.49) | MMP2MMP3MMP9MMP8MMP13 | |
| SCHEMBL6500186 | 0.65 | SLC6A3 (0.57) | KIF11 | |
| SCHEMBL1464281 | 0.65 | MMP2 (0.51) | MMP2MMP3MMP9MMP8MMP13 | |
| SCHEMBL17761224 | 0.65 | SLC6A3 (0.53) | KIF11 | |
| SCHEMBL6494941 | 0.64 | SLC6A3 (0.60) | KIF11 | |
| SCHEMBL14242993 | 0.64 | PTGS2 (0.44) | MMP2MMP3MMP9MMP8MMP13 | |
| SCHEMBL17689396 | 0.63 | PTGS2 (0.47) | MMP2MMP3MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633743-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ | Amgen, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004092164-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ | AMGEN, INC. (US) | 2004-10-28 | — | — | WO | disclosed |