Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 4/20 | 0.52 |
| ▸ | TUBB | P07437 | 4/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17366133 | 0.95 | TUBB4A (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13660015 | 0.90 | MIF (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5689279 | 0.88 | TUBB4A (0.49) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL15460411 | 0.87 | PTPN1 (0.45) | MAPTHSD17B10ALDH1A1PTPN1TSHR | |
| SCHEMBL15463035 | 0.86 | MAPT (0.48) | MAPTHSD17B10USP2ALDH1A1LMNA | |
| SCHEMBL13644528 | 0.84 | USP2 (0.53) | MAPTHSD17B10USP2ALDH1A1LMNA | |
| SCHEMBL13362374 | 0.84 | USP2 (0.53) | MAPTHSD17B10USP2ALDH1A1LMNA | |
| SCHEMBL1015152 | 0.83 | MIF (0.57) | MAPTHSD17B10USP2ALDH1A1LMNA | |
| SCHEMBL13643398 | 0.83 | PTPN1 (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL12687453 | 0.82 | S1PR1 (0.48) | MAPTHSD17B10USP2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160773-A1 | Combretastatin derivatives with cytotoxic action | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-07-20 | — | — | US | claimed |
| EP-1646616-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-04-19 | — | — | EP | claimed |
| WO-2005007635-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-01-27 | — | — | WO | claimed |
| EP-2350030-B9 | ISOXAZOLE/ISOXAZOLINE/COMBRETASTATIN LINKED DIHYDROQUINAZOLINONE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2016-10-26 | — | — | EP | disclosed |
| EP-2350030-B1 | ISOXAZOLE/ISOXAZOLINE/COMBRETASTATIN LINKED DIHYDROQUINAZOLINONE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2016-04-20 | — | — | EP | disclosed |
| EP-2670740-B1 | AMIDOBENZOTHIAZOLES AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2015-12-30 | — | — | EP | disclosed |
| US-9102638-B2 | Amidobenzothiazoles and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-08-11 | — | — | US | disclosed |
| EP-2670739-B1 | BENZOTHIAZOLE HYBRIDS USEFUL AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2015-04-01 | — | — | EP | disclosed |
| US-8921552-B2 | Benzothiazole hybrids useful as anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-12-30 | — | — | US | disclosed |
| US-8921552-B2 | Benzothiazole hybrids useful as anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-12-30 | — | — | US | disclosed |
| US-8883809-B2 | Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-11-11 | — | — | US | disclosed |
| US-8883809-B2 | Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-11-11 | — | — | US | disclosed |
| US-20140039190-A1 | BENZOTHIAZOLE HYBRIDS USEFUL AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-02-06 | — | — | US | disclosed |
| US-20140039190-A1 | BENZOTHIAZOLE HYBRIDS USEFUL AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-02-06 | — | — | US | disclosed |
| US-20120283439-A1 | ISOXAZOLE/ISOXAZOLINE/COMBRETASTATIN LINKED DIHYDROQUINAZOLINONE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Redearch (IN) | 2012-11-08 | — | — | US | disclosed |
| WO-2012104875-A1 | BENZOTHIAZOLE HYBRIDS USEFUL AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-08-09 | — | — | WO | disclosed |
| WO-2010058417-A1 | ISOXAZOLE/ISOXAZOLINE/COMBRETASTATIN LINKED DIHYDROQUINAZOLINONE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-27 | — | — | WO | disclosed |
| EP-1646616-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005007635-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140039190-A1 | BENZOTHIAZOLE HYBRIDS USEFUL AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | TP53, MCL1, SDHA | TUBB4A 40/4885TUBB 112/4885TUBA3C 435/4885 |
| US-20120283439-A1 | ISOXAZOLE/ISOXAZOLINE/COMBRETASTATIN LINKED DIHYDROQUINAZOLINONE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | NDUFAF1, TOP1, COX4I1 | TUBB4A 67/4885TUBB 161/4885TUBA3C 115/4885 |
| US-20060160773-A1 | Combretastatin derivatives with cytotoxic action | TUBB, TUBB1, TYMS | TUBB4A 6/4885TUBB 1/4885TUBA3C 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.