SCHEMBL568868

SCHEMBL568868

Nc1ccnn1Cc1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.72
ALDH1A1 P00352 3/20 0.69
PKM P14618 1/20 0.69
TSHR P16473 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.50
P2RX7 Q99572 1/20 0.50
CYP19A1 P11511 1/20 0.50
POLB P06746 2/20 0.47
GAA P10253 2/20 0.47
HPGD P15428 2/20 0.47
ALOX15 P16050 1/20 0.47
HSD17B10 Q99714 1/20 0.47
RECQL P46063 1/20 0.46
MEN1 O00255 1/20 0.44
GALR3 O60755 1/20 0.44
MAPT P10636 1/20 0.44
NPY1R P25929 1/20 0.44
STAT3 P40763 1/20 0.44
NPY2R P49146 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6760429 0.90 KDM4E (0.81) KDM4EALDH1A1PKMTSHRSMN1; SMN2
SCHEMBL11060615 0.87 KDM4E (0.57) KDM4EALDH1A1PKMTSHRSMN1; SMN2
SCHEMBL1491076 0.85 KDM4E (0.58) KDM4EALDH1A1PKM
SCHEMBL1491092 0.84 KDM4E (0.54) KDM4EALDH1A1PKMSMN1; SMN2GAA
SCHEMBL11063623 0.84 KDM4E (0.54) KDM4EALDH1A1PKMTSHRSMN1; SMN2
SCHEMBL1491110 0.84 KDM4E (1.00) KDM4EALDH1A1PKMTSHRSMN1; SMN2
SCHEMBL1491127 0.83 KDM4E (0.60) KDM4EALDH1A1PKMSMN1; SMN2P2RX7
SCHEMBL1491057 0.82 KDM4E (0.70) KDM4EALDH1A1PKMTSHRSMN1; SMN2
SCHEMBL1491102 0.82 ALDH1A1 (1.00) KDM4EALDH1A1PKMP2RX7
SCHEMBL11394214 0.81 KDM4E (0.50) KDM4EALDH1A1PKMTSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative L'OREAL S.A. 2007-06-14 US claimed
EP-1434552-A1 METHOD FOR DYEING KERATINOUS FIBRES Henkel Kommanditgesellschaft auf Aktien (DE) 2004-07-07 EP claimed
WO-2003030841-A1 METHOD FOR DYEING KERATINOUS FIBRES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2003-04-17 WO claimed
CN-119384474-A Liquid composition and optical film 日本瑞翁株式会社 2025-01-28 CN disclosed
CN-119053889-A Multilayer film, method for producing same, polarizing plate, and organic electroluminescent image display device 日本瑞翁株式会社 2024-11-29 CN disclosed
CN-117957114-A Multilayer film, optical multilayer film, and method for producing same 日本瑞翁株式会社 2024-04-30 CN disclosed
WO-2024024467-A1 LIQUID COMPOSITION AND OPTICAL FILM 日本ゼオン株式会社 2024-02-01 WO disclosed
WO-2023233958-A1 MULTILAYER FILM AND METHOD FOR MANUFACTURING SAME, POLARIZING PLATE, AND ORGANIC ELECTROLUMINESCENT IMAGE DISPLAY DEVICE 日本ゼオン株式会社 2023-12-07 WO disclosed
US-20230339970-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-10-26 US disclosed
US-20230339900-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-10-26 US disclosed
CN-111443415-B Polarizing plate 住友化学株式会社 2023-08-01 CN disclosed
US-4246410-A BENZINDOLE DYES OF YELLOW AND RED CIBA -GEIGY AKTIENGESELLSCHAFT (CH) 1981-01-20 US disclosed
US-4128545-A DISPERSE, POLYESTER BASF AKTIENGESELLSCHAFT (DE) 1978-12-05 US disclosed
US-4128717-A Derivatives of 5,6-dihydrobenzo[5,6]cyclohepta[1,2-B]pyrazolo-[4,3-E]pyridin-11 (1H)-ones and 11 (1H)-imines E. R. SQUIBB & SONS, INC. (US) 1978-12-05 US disclosed
US-4113720-A Disperse azo dye with diaminopyrimidine coupling component BASF AKTIENGESELLSCHAFT (DE) 1978-09-12 US disclosed
US-4062858-A Derivatives of 5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)-ones and 11(1H)-imines E. R. SQUIBB & SONS, INC. (US) 1977-12-13 US disclosed
US-4042578-A POLYESTERS BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1977-08-16 US disclosed
US-4041025-A FOR HYDROPHOBIC FIBERS SUCH AS POLYESTERS, YELLOW TO BLUE-GREEN SHADES BASF AKTIENGESELLSCHAFT (DT) 1977-08-09 US disclosed
US-4018779-A Derivatives of 10,11-dihydrobenzo[4,5]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine-5(1H)ones E. R. SQUIBB & SONS, INC. (US) 1977-04-19 US disclosed
US-3957782-A Pyrazolo [3,4-b]pyrazine-5-carboxylic acids, esters, nitriles and amides E. R. SQUIBB & SONS, INC. (US) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230339900-A1 CASEIN KINASE 1 DELTA MODULATORS CSNK1D, CSNK1A1, CSNK2A1 KDM4E 2449/4885ALDH1A1 1600/4885PKM 621/4885
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative KRT18, NDUFB5, NDUFB7 KDM4E 440/4885ALDH1A1 83/4885PKM 196/4885
US-20230339970-A1 CASEIN KINASE 1 DELTA MODULATORS CSNK1D, CSNK1A1, CSNK1G1 KDM4E 2194/4885ALDH1A1 1482/4885PKM 593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.