Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453612 | 0.83 | NPC1 (0.51) | CA2CA1CA12CA4CA6 | |
| SCHEMBL13886412 | 0.78 | ALDH1A1 (0.38) | OPRK1APLNR | |
| SCHEMBL13319989 | 0.78 | CA2 (0.47) | CA2OPRK1APLNRKDM4E | |
| SCHEMBL3060002 | 0.76 | APLNR (0.39) | CA2CA1CA7CA9TDP1 | |
| SCHEMBL5479553 | 0.76 | APLNR (0.39) | CA2CA1CA7CA9TDP1 | |
| SCHEMBL2598795 | 0.74 | HRH3 (0.50) | CA2TDP1TSHROPRK1APLNR | |
| SCHEMBL1434498 | 0.74 | CA2 (0.64) | CA2CA1CA12CA4CA6 | |
| SCHEMBL5994202 | 0.73 | PPARA (0.49) | CA2CA1CA12CA4CA6 | |
| SCHEMBL66152 | 0.73 | ALDH1A1 (0.58) | CA2CYP4F2CYP4A11TDP1TSHR | |
| SCHEMBL1334344 | 0.73 | ENPP2 (0.50) | CA2CA1CA12CA4CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638927-A1 | THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004113282-A1 | THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |