Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5692376 | 0.84 | PTGS1 (0.42) | CA1CA2HPGDPTGS1TRPA1 | |
| SCHEMBL5693100 | 0.82 | GABRA1 (0.44) | GABRA1GABRB2TRPA1 | |
| SCHEMBL7525526 | 0.79 | TRPV1 (0.36) | GABRA1GABRB1GABRB2GABRA5GABRA3 | |
| SCHEMBL5692101 | 0.78 | ALOX5 (0.34) | GABRA1GABRB2TRPA1ALDH1A1DHFR | |
| SCHEMBL6676515 | 0.78 | SCN2A (0.43) | GABRA1GABRB2GSRCA1CA2 | |
| SCHEMBL6680819 | 0.76 | PTGS1 (0.39) | PTGS1TRPA1ALDH1A1 | |
| SCHEMBL5692254 | 0.76 | NPC1 (0.36) | HPGDMAPK1 | |
| SCHEMBL9223934 | 0.75 | POLB (0.42) | HPGDMAPTMEN1ALDH1A1ALOX15 | |
| SCHEMBL7517733 | 0.73 | TRPA1 (0.34) | TRPA1MAPTALDH1A1MAPK1HSD17B10 | |
| SCHEMBL27455332 | 0.73 | GABRA1 (0.39) | GABRA1GABRB1GABRB2GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468692-B1 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMA INC (US) | 2006-04-26 | — | — | EP | disclosed |
| EP-0732928-B1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMA INC (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-1468692-A2 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1468693-A2 | Use of 2,6-di -alkyl-4-silyl-phenols for treating diabetes mellitus | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| US-5532400-A | 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0464852-B1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5155250-A | 2,6-DI-ALKYL-4-SILYL-PHENOLS AS ANTIATHEROSCEROTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0464852-A1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |