SCHEMBL5693422

SCHEMBL5693422

C=CCNC(=O)OCCc1ccc(O)c(-n2nc3ccc(C(F)(F)F)cc3n2)c1

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 4/20 0.32
LMNA P02545 1/20 0.32
RECQL P46063 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ALOX5 P09917 1/20 0.32
YWHAG P61981 1/20 0.31
APP P05067 1/20 0.31
FFAR4 Q5NUL3 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5693420 0.85 GAA (0.35) LMNARECQLSMN1; SMN2ALOX5MEN1
SCHEMBL5693426 0.85 FFAR4 (0.33) RAF1LMNAALOX5YWHAGAPP
SCHEMBL5693449 0.82 ALDH1A1 (0.34) LMNARECQLSMN1; SMN2ALOX5MEN1
SCHEMBL5693441 0.81 GAA (0.38) MEN1KMT2A
SCHEMBL7681875 0.81 ALOX5 (0.42) LMNASMN1; SMN2ALOX5APPMEN1
SCHEMBL3956215 0.81 MET (0.36) LMNAALOX5APPFFAR4MEN1
SCHEMBL3949720 0.79 GAA (0.41) RAF1
SCHEMBL5693442 0.77 FFAR4 (0.40) RAF1LMNAALOX5FFAR4
SCHEMBL25409102 0.77 APP (0.36) LMNAALOX5YWHAGAPPMEN1
SCHEMBL3951410 0.76 FFAR4 (0.33) RAF1LMNAFFAR4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1305320-B1 PHOTOSTABLE, SILYLATED BENZOTRIAZOLE UV ABSORBERS AND COMPOSITIONS STABILIZED THEREWITH CIBA SC HOLDING AG (CH) 2006-05-31 EP disclosed
US-6677392-B2 USED TO STABILIE NATURAL, SEMI-SYNTHETIC OR SYNTHETIC POLYMER. CIBA SPECIALTY CHEMICALS CORPORATION 2004-01-13 US disclosed
EP-1305320-A1 PHOTOSTABLE, SILYLATED BENZOTRIAZOLE UV ABSORBERS AND COMPOSITIONS STABILIZED THEREWITH Ciba SC Holding AG (CH) 2003-05-02 EP disclosed
US-20020115753-A1 Photostable, silylated benzotriazole UV absorbers and compositions stabilized therewith RAVICHANDRAN RAMANATHAN (US) 2002-08-22 US disclosed
WO-2002012252-A1 PHOTOSTABLE, SILYLATED BENZOTRIAZOLE UV ABSORBERS AND COMPOSITIONS STABILIZED THEREWITH CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2002-02-14 WO disclosed