Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81650 | 0.71 | NISCH (0.59) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL297602 | 0.69 | NISCH (0.48) | NISCHMTORADKALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL1536214 | 0.69 | NISCH (0.56) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL28425230 | 0.69 | NISCH (0.56) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL2706724 | 0.68 | NISCH (0.42) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL2084172 | 0.68 | NISCH (0.42) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL7392336 | 0.68 | NISCH (0.42) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL3612034 | 0.68 | ALDH1A1 (0.46) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL295727 | 0.68 | NISCH (0.52) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL722191 | 0.67 | NISCH (0.78) | NISCHMTORADKALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966446-B1 | BICYCLIC INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER LAMBERT CO (US) | 2005-10-19 | — | — | EP | claimed |
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | claimed |
| EP-0530537-B1 | Condensed pyrimidine derivatives, their production and use as antitumor agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-01-08 | — | — | EP | claimed |
| EP-0602522-B1 | Substituted Benzoylguanidines, method for their preparation, their use as antiarrhythmic agents | HOECHST AG (DE) | 1996-05-29 | — | — | EP | claimed |
| EP-0558673-B1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO CO (US) | 1996-04-17 | — | — | EP | claimed |
| EP-2601190-B1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-2814825-B1 | DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2016-03-23 | — | — | EP | disclosed |
| US-9133172-B2 | Dihydrofuran azetidine derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-09-15 | — | — | US | disclosed |
| US-9073912-B2 | Azetidine derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-07-07 | — | — | US | disclosed |
| US-9061013-B2 | Isoxazoline derivatives as antiparasitic agents | ZOETIS LLC (US) | 2015-06-23 | — | — | US | disclosed |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2015-04-30 | — | — | US | disclosed |
| EP-2855457-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | Zoetis Products LLC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2012-02-09 | — | — | US | disclosed |
| WO-2012017359-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-02-09 | — | — | WO | disclosed |
| EP-0966446-B1 | BICYCLIC INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER LAMBERT CO (US) | 2005-10-19 | — | — | EP | disclosed |
| US-6787556-B1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) AGONISTS; type 2 gamma receptors; INSULIN RESISTANCE; carboxybenzyl group on a phenyl-substituted tetrazole, pyrazole, or imidazole ring | ASTRAZENECA AB (SE) | 2004-09-07 | — | — | US | disclosed |
| US-20020042422-A1 | Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands | NEUROGEN CORPORATION | 2002-04-11 | — | — | US | disclosed |
| US-5674864-A | ANALGESICS; ENDOPEPTIDASE AND ENKEPHALINASE INHIBITORS; CARDIOTONIC, PSYCHOTROPIC AND HYPERTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1997-10-07 | — | — | US | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| US-5190974-A | Analgesics | ROUSSEL UCLAF (FR) | 1993-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ADORA1, CYP3A7, RDX | NISCH 166/4885MTOR 2769/4885ADK 1289/4885 |
| US-20020042422-A1 | Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands | CRH, CRHR1, CRHR2 | NISCH 3247/4885MTOR 849/4885ADK 1162/4885 |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | CYP1B1, ADORA1, QDPR | NISCH 58/4885MTOR 2290/4885ADK 2143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.