SCHEMBL5695964

SCHEMBL5695964

C=C(C#N)S(=O)(=O)c1cccc(-c2cccc(OC=CC)c2)c1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
C1S P09871 1/20 0.32
KAT6A Q92794 1/20 0.32
PTGES2 Q9H7Z7 1/20 0.32
FAAH O00519 2/20 0.31
NAAA Q02083 2/20 0.31
HSD11B1 P28845 1/20 0.30
CTSL P07711 2/20 0.30
CTSS P25774 2/20 0.30
CTSK P43235 2/20 0.30
CTSB P07858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5695962 0.92 MEN1 (0.38) MEN1KMT2AFAAHNAAACTSS
SCHEMBL28764074 0.73 HPGD (0.41) MEN1KMT2AKAT6A
SCHEMBL5696010 0.71 PTGS2 (0.38) MEN1KMT2A
SCHEMBL28938490 0.70 KMT2A (0.44) MEN1KMT2A
SCHEMBL742011 0.66 PKM (0.46) MEN1KMT2A
SCHEMBL5612567 0.66 ACHE (0.34) MEN1KMT2A
SCHEMBL28459005 0.63 AKR1C3 (0.56) KMT2A
Sulfuric Acid SCHEMBL21110867 0.62 CA1 (0.38) MEN1KMT2A
SCHEMBL9863367 0.62 CYP3A4 (0.48)
SCHEMBL757113 0.61 SMN1; SMN2 (0.51) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1371654-B1 Sunscreen compositions containing silane or siloxane derivatives of phenylsulfon acrylonitrile, phenylsulfon acrylonitrile derivatives and their use as UV filter OREAL (FR) 2006-06-14 EP claimed
EP-1371654-A1 Sunscreen compositions containing silane or siloxane derivatives of phenylsulfon acrylonitrile, phenylsulfon acrylonitrile derivatives and their use as UV filter L'OREAL (FR) 2003-12-17 EP claimed
EP-1371654-B1 Sunscreen compositions containing silane or siloxane derivatives of phenylsulfon acrylonitrile, phenylsulfon acrylonitrile derivatives and their use as UV filter OREAL (FR) 2006-06-14 EP disclosed
EP-1371654-A1 Sunscreen compositions containing silane or siloxane derivatives of phenylsulfon acrylonitrile, phenylsulfon acrylonitrile derivatives and their use as UV filter L'OREAL (FR) 2003-12-17 EP disclosed