SCHEMBL5696554

SCHEMBL5696554

CCS(=O)(=O)[CH]c1ccccc1OC(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.44
LMNA P02545 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
PTGES2 Q9H7Z7 1/20 0.43
MAPT P10636 4/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
KDM4E B2RXH2 2/20 0.43
HTT P42858 1/20 0.43
POLB P06746 1/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
DRD1 P21728 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
GAA P10253 1/20 0.37
TNF P01375 1/20 0.36
RAB9A P51151 1/20 0.36
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13012150 0.84 PTGES2 (0.53) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL14686367 0.83 L3MBTL1 (0.46) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL29538287 0.73 ALDH1A1 (0.55) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL908602 0.73 ALDH1A1 (0.55) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL13012170 0.71 PTGES2 (0.55) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL5807443 0.70 L3MBTL1 (0.56) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL18441111 0.70 L3MBTL1 (0.46) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL5807441 0.70 L3MBTL1 (0.56) HPGDLMNAL3MBTL1PTGES2MAPT
SCHEMBL13012151 0.70 PTGES2 (0.54) LMNAL3MBTL1PTGES2MAPTSMN1; SMN2
SCHEMBL3366569 0.70 TNF (0.49) HPGDLMNAL3MBTL1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1663958-A2 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2006-06-07 EP disclosed
WO-2005028429-A2 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2005-03-31 WO disclosed