Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nylidrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | DRD3 | P35462 | 2/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nylidrin SCHEMBL364078 | 0.82 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| Nylidrin SCHEMBL15512520 | 0.81 | HIF1A (0.95) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| Nylidrin SCHEMBL3701975 | 0.81 | HIF1A (1.00) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| Nylidrin SCHEMBL159150 | 0.81 | HIF1A (1.00) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| Nylidrin SCHEMBL15517085 | 0.81 | HIF1A (1.00) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| Nylidrin SCHEMBL9352972 | 0.73 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| SCHEMBL17565768 | 0.72 | SLC6A2 (0.80) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| Nylidrin SCHEMBL4915449 | 0.71 | ADRB2 (0.61) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| Nylidrin SCHEMBL9653633 | 0.71 | LMNA (0.56) | ADRA1AADRA1DADRA1BBLMHIF1A | |
| SCHEMBL29084637 | 0.70 | TDP1 (0.77) | ADRA1ABLMADRA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680148-A1 | HYDROGEL-CONTAINING MEDICAL ARTICLES AND METHODS OF USING AND MAKING THE SAME | BIOARTIFICIAL GEL TECHNOLOGIES INC. (CA) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005037336-A1 | HYDROGEL-CONTAINING MEDICAL ARTICLES AND METHODS OF USING AND MAKING THE SAME | BIOARTIFICIAL GEL TECHNOLOGIES INC. (CA) | 2005-04-28 | — | — | WO | disclosed |