Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.80 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.80 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.80 |
| ▸ | HTR1A | P08908 | 2/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.80 |
| ▸ | DRD3 | P35462 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nylidrin SCHEMBL15517085 | 0.89 | HIF1A (1.00) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| Nylidrin SCHEMBL159150 | 0.89 | HIF1A (1.00) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| Nylidrin SCHEMBL3701975 | 0.89 | HIF1A (1.00) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| Nylidrin SCHEMBL364078 | 0.87 | ADRA1A (1.00) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| Nylidrin SCHEMBL15512520 | 0.86 | HIF1A (0.95) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| Bufeniode SCHEMBL309865 | 0.80 | ADRA1A (0.70) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| SCHEMBL5270601 | 0.79 | MAPK1 (0.66) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| Nylidrin SCHEMBL13724281 | 0.76 | ADRB2 (0.73) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| SCHEMBL9640991 | 0.75 | SIGMAR1 (0.64) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 | |
| SCHEMBL10021106 | 0.75 | PPARG (0.48) | SLC6A2SLC6A3ADRA1AHIF1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160067240-A1 | NOVEL ALLOSTERIC INHIBITORS OF THYMIDYLATE SYNTHASE | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160067240-A1 | NOVEL ALLOSTERIC INHIBITORS OF THYMIDYLATE SYNTHASE | GLS, MCL1, TYMS | SLC6A2 4677/4885SLC6A3 4041/4885ADRA1A 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.