Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 5/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696981 | 0.94 | PLA2G2A (0.49) | PLA2G2APLA2G1BPLA2G10PLA2G5PSEN1 | |
| SCHEMBL5696902 | 0.84 | PSEN1 (0.43) | PLA2G2APLA2G1BPSEN1PSEN2APH1B | |
| SCHEMBL2157014 | 0.83 | PLA2G2A (0.52) | PLA2G2APLA2G1BPLA2G10PLA2G5PSEN1 | |
| SCHEMBL5697008 | 0.82 | MTNR1A (0.52) | PLA2G2APLA2G1BPLA2G10PLA2G5PSEN1 | |
| SCHEMBL5697018 | 0.78 | PLA2G2A (0.55) | PLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL2157143 | 0.76 | PLA2G2A (0.53) | PLA2G2APLA2G1BPLA2G10PLA2G5PSEN1 | |
| SCHEMBL4789355 | 0.74 | PLA2G1B (0.46) | PLA2G2APLA2G1BPSEN1PSEN2APH1B | |
| SCHEMBL2156559 | 0.74 | MTNR1B (0.49) | PLA2G2APLA2G1BPLA2G10PLA2G5HTT | |
| SCHEMBL2156650 | 0.72 | PLA2G2A (0.52) | PLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL5697108 | 0.71 | PLA2G2A (0.61) | PLA2G2APLA2G1BPLA2G10PLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100492-B1 | INDOLE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2006-05-24 | — | — | EP | disclosed |
| US-6451839-B1 | Indole sPLA2 inhibitors | ELI LILLY AND COMPANY | 2002-09-17 | — | — | US | disclosed |
| EP-1100492-A4 | INDOLE sPLA 2? INHIBITORS | LILLY CO ELI (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1100492-A1 | INDOLE sPLA 2? INHIBITORS | Eli Lilly & Company (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000007590-A1 | INDOLE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-02-17 | — | — | WO | disclosed |