Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696981 | 0.87 | PLA2G2A (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5697008 | 0.86 | MTNR1A (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5697202 | 0.84 | PLA2G2A (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4789355 | 0.77 | PLA2G1B (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5697060 | 0.76 | PLA2G2A (0.46) | PLA2G2APLA2G1B | |
| SCHEMBL2157014 | 0.76 | PLA2G2A (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25136 | 0.74 | MTNR1B (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14277707 | 0.72 | GRM4 (0.51) | DDB1CRBNMAPTALDH1A1KDM4E | |
| SCHEMBL5697619 | 0.69 | DDB1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4757197 | 0.69 | MTNR1B (0.52) | MTNR1BMTNR1AMAPTPLA2G2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100492-B1 | INDOLE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2006-05-24 | — | — | EP | disclosed |
| EP-1100492-A4 | INDOLE sPLA 2? INHIBITORS | LILLY CO ELI (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1100492-A1 | INDOLE sPLA 2? INHIBITORS | Eli Lilly & Company (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000007590-A1 | INDOLE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-02-17 | — | — | WO | disclosed |