Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 2/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157708 | 0.88 | PLA2G2A (0.50) | PLA2G1BPLA2G2AALDH1A1HPGDL3MBTL1 | |
| SCHEMBL2157014 | 0.86 | PLA2G2A (0.52) | PLA2G1BPLA2G2AMTNR1BMTNR1APSEN1 | |
| SCHEMBL25136 | 0.85 | MTNR1B (0.60) | PLA2G1BPLA2G2AMTNR1BMTNR1APSEN1 | |
| SCHEMBL4757197 | 0.80 | MTNR1B (0.52) | PLA2G1BPLA2G2AMTNR1BMTNR1AALDH1A1 | |
| SCHEMBL2157143 | 0.79 | PLA2G2A (0.53) | PLA2G1BPLA2G2AMTNR1BMTNR1APSEN1 | |
| SCHEMBL5696902 | 0.77 | PSEN1 (0.43) | PLA2G1BPLA2G2AMTNR1BMTNR1AALDH1A1 | |
| SCHEMBL5696981 | 0.76 | PLA2G2A (0.49) | PLA2G1BPLA2G2AMTNR1BMTNR1AHPGD | |
| SCHEMBL5162627 | 0.76 | ALDH1A1 (0.68) | ALDH1A1HPGDL3MBTL1CYP2C19TSHR | |
| SCHEMBL14620974 | 0.74 | MTNR1B (0.52) | PLA2G1BPLA2G2AMTNR1BMTNR1AALDH1A1 | |
| SCHEMBL5697008 | 0.74 | MTNR1A (0.52) | PLA2G1BPLA2G2AMTNR1BMTNR1APSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950200-A1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid methyl ester as sPLA2 inhibitor | ELI LILLY AND COMPANY (US) | 2008-07-30 | — | — | EP | disclosed |