Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CTSE | P14091 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17729489 | 0.83 | MAPT (0.51) | RORC | |
| SCHEMBL18588038 | 0.83 | RORC (0.41) | RORCNR1H2USP2SMN1; SMN2 | |
| SCHEMBL1310475 | 0.83 | RORC (0.49) | RORC | |
| SCHEMBL569651 | 0.83 | RORC (0.55) | RORCNR1H2 | |
| SCHEMBL31084071 | 0.83 | MEN1 (0.52) | RORCHTTUSP2SMN1; SMN2POLB | |
| SCHEMBL1309072 | 0.82 | RORC (0.51) | RORCATM | |
| SCHEMBL16292154 | 0.82 | GPR119 (0.51) | RORCNR1H2 | |
| SCHEMBL16874872 | 0.82 | ALDH1A1 (0.51) | RORCHTTSMN1; SMN2CTSDCTSE | |
| SCHEMBL20341701 | 0.81 | RORC (0.40) | RORCNR1H2USP2SMN1; SMN2CTSD | |
| SCHEMBL21826368 | 0.81 | HTT (0.52) | RORCHTTATMNR1H2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601190-B1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-2601190-B1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2018-07-04 | — | — | EP | disclosed |
| US-9073912-B2 | Azetidine derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073912-B2 | Azetidine derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073912-B2 | Azetidine derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-07-07 | — | — | US | disclosed |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2015-04-30 | — | — | US | disclosed |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2015-04-30 | — | — | US | disclosed |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2015-04-30 | — | — | US | disclosed |
| EP-2855457-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | Zoetis Products LLC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-20140371464-A1 | PROCESS FOR THE PREPARATION OF CHIRAL ISOXAZOLINE AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2014-12-18 | — | — | US | disclosed |
| WO-2013169622-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS LLC (US) | 2013-11-14 | — | — | WO | disclosed |
| WO-2013116236-A1 | PROCESS FOR THE PREPARATION OF CHIRAL ISOXAZOLINE AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS LLC (US) | 2013-08-08 | — | — | WO | disclosed |
| WO-2013116236-A1 | PROCESS FOR THE PREPARATION OF CHIRAL ISOXAZOLINE AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS LLC (US) | 2013-08-08 | — | — | WO | disclosed |
| EP-2601190-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | AH USA 42 LLC (US) | 2013-06-12 | — | — | EP | disclosed |
| US-8415310-B2 | Isoxazoline derivatives as antiparasitic agents | AH USA 42 LLC (US) | 2013-04-09 | — | — | US | disclosed |
| US-8415310-B2 | Isoxazoline derivatives as antiparasitic agents | AH USA 42 LLC (US) | 2013-04-09 | — | — | US | disclosed |
| US-8415310-B2 | Isoxazoline derivatives as antiparasitic agents | AH USA 42 LLC (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2012-02-09 | — | — | US | disclosed |
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2012-02-09 | — | — | US | disclosed |
| WO-2012017359-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ADORA1, CYP3A7, RDX | RORC 519/4885HTT 2211/4885ATM 3520/4885 |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | CYP1B1, ADORA1, QDPR | RORC 1226/4885HTT 1298/4885ATM 4802/4885 |
| US-20140371464-A1 | PROCESS FOR THE PREPARATION OF CHIRAL ISOXAZOLINE AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | RDX, CYP2C9, CYP1A2 | RORC 106/4885HTT 2670/4885ATM 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.