Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TFEB | P19484 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458059 | 0.87 | LMNA (0.58) | NFE2L2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL458060 | 0.87 | LMNA (0.58) | NFE2L2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL458476 | 0.81 | NFE2L2 (0.69) | NFE2L2ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL458477 | 0.81 | NFE2L2 (0.69) | NFE2L2ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL528919 | 0.81 | PTGER4 (0.68) | NFE2L2PTGER1PTGER4PTGER3PTGER2 | |
| Methylamine SCHEMBL15948926 | 0.80 | NFE2L2 (0.67) | NFE2L2ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL20339063 | 0.77 | MAPT (0.68) | NFE2L2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL12425714 | 0.74 | NFKB1 (0.63) | NFE2L2ALDH1A1KDM4ELMNAHDAC1 | |
| SCHEMBL4254014 | 0.74 | NFKB1 (0.63) | NFE2L2ALDH1A1KDM4ELMNAHDAC1 | |
| SCHEMBL29412622 | 0.74 | NFKB1 (0.63) | NFE2L2ALDH1A1KDM4ELMNAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |