Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099968 | 0.79 | TPH1 (0.41) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5096945 | 0.76 | PLA2G7 (0.43) | P2RX7MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL5093247 | 0.76 | HTR3A (0.41) | P2RX7LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5093298 | 0.76 | POLB (0.43) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5099602 | 0.75 | TPH1 (0.34) | NAAAHDAC1MAPTPLA2G1BATG4B | |
| SCHEMBL5099387 | 0.73 | CNR1 (0.48) | P2RX7ALDH1A1PLA2G1BATG4BMEN1 | |
| SCHEMBL5105809 | 0.71 | XIAP (0.41) | MAPTALDH1A1LMNA | |
| SCHEMBL5093211 | 0.71 | MAOA (0.41) | HDAC1MEN1KMT2A | |
| SCHEMBL17594208 | 0.69 | CA12 (0.45) | MAPTALDH1A1LMNACYP2C9CYP2C19 | |
| SCHEMBL5099405 | 0.67 | ACLY (0.46) | HDAC1ALDH1A1PLA2G1BATG4BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689719-A1 | 7-PHENYL-ISOQUINOLINE-5-SULFONYLAMINO DERIVATIVES AS INHIBITORS OF AKT (PROTEINKINASE B) | ELI LILLY AND COMPANY (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005054202-A1 | 7-PHENYL-ISOQUINOLINE-5-SULFONYLAMINO DERIVATIVES AS INHIBITORS OF AKT (PROTEINKINASE B) | ELI LILLY AND COMPANY (US) | 2005-06-16 | — | — | WO | disclosed |