Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1280729 | 0.86 | PTGS2 (0.38) | ACHEPTGS2BCHEDPP4NPC1 | |
| SCHEMBL2867341 | 0.79 | PARP1 (0.37) | PARP1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11061904 | 0.76 | PTGS2 (0.39) | ACHEPTGS2BCHEALDH1A1NPC1 | |
| SCHEMBL29520274 | 0.76 | PTGS2 (0.39) | ACHEPTGS2BCHEALDH1A1NPC1 | |
| SCHEMBL2047871 | 0.75 | ADRB2 (0.36) | ACHEPTGS2BCHE | |
| SCHEMBL13933019 | 0.74 | KDM4E (0.38) | PARP1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL508188 | 0.74 | PTGS2 (0.50) | ACHEPTGS2BCHECYP1A2NPSR1 | |
| SCHEMBL21205740 | 0.74 | PARP1 (0.45) | PARP1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL4066734 | 0.73 | KDM4E (0.37) | PARP1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6394314 | 0.73 | PTGS2 (0.57) | ACHEPTGS2BCHECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601190-B1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-2601190-B1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2018-07-04 | — | — | EP | disclosed |
| CN-103517907-B | Volution isoxazolines derivative as antiparasitic | 硕腾服务有限责任公司 | 2016-07-06 | — | — | CN | disclosed |
| EP-2683723-A1 | SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | Zoetis LLC (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8466115-B2 | Spirocyclic isoxazoline derivatives as antiparasitic agents | ZOETIS LLC (US) | 2013-06-18 | — | — | US | disclosed |
| US-8466115-B2 | Spirocyclic isoxazoline derivatives as antiparasitic agents | ZOETIS LLC (US) | 2013-06-18 | — | — | US | disclosed |
| US-8466115-B2 | Spirocyclic isoxazoline derivatives as antiparasitic agents | ZOETIS LLC (US) | 2013-06-18 | — | — | US | disclosed |
| EP-2601190-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | AH USA 42 LLC (US) | 2013-06-12 | — | — | EP | disclosed |
| US-8415310-B2 | Isoxazoline derivatives as antiparasitic agents | AH USA 42 LLC (US) | 2013-04-09 | — | — | US | disclosed |
| US-8415310-B2 | Isoxazoline derivatives as antiparasitic agents | AH USA 42 LLC (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2012-02-09 | — | — | US | disclosed |
| CN-1297874-A | Preparation of benzaldehyde dialkyl acetal or substituted benzaldehyde dialkyl acetal | SHANDONG PROV INST OF AGRICULT (CN) | 2001-06-06 | — | — | CN | disclosed |
| EP-0048411-B1 | PROCESS FOR PREPARING 3-BROMO-4-FLUORO-BENZALDEHYDE ACETALS, INTERMEDIATES AND THEIR PREPARATION | BAYER AG (DE) | 1986-11-12 | — | — | EP | disclosed |
| EP-0044139-B1 | NEW CYCLOPROPANECARBOXYLATES, THEIR PRODUCTION AND A LOW FISH TOXIC INSECTICIDE AND/OR ACARICIDE CONTAINING THEM AS AN ACTIVE INGREDIENT | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-09-26 | — | — | EP | disclosed |
| EP-0044002-B1 | PROCESS FOR PREPARING 3-BROMO-4-FLUOROBENZALDEHYDE (-ACETALS),3-BROMO- 4-FLUORO-BENZOIC ACID NITRILE AND ITS PREPARATION | BAYER AG (DE) | 1983-07-20 | — | — | EP | disclosed |
| US-4383949-A | Preparation of 3-bromo-4-fluorobenzaldehyde and its acetals | BAYER AKTIENGESELLSCHAFT (DE) | 1983-05-17 | — | — | US | disclosed |
| US-4376785-A | Cyclopropanecarboxylates and a low fish toxic insecticide and/or acaricide containing them | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-03-15 | — | — | US | disclosed |
| US-4348538-A | IMINES, GLYOCYLIC ACIDS, BENZOYL CYANIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | disclosed |
| EP-0048411-A2 | Process for preparing 3-bromo-4-fluoro-benzaldehyde acetals, intermediates and their preparation | BAYER AG (DE) | 1982-03-31 | — | — | EP | disclosed |
| EP-0044139-A2 | New cyclopropanecarboxylates, their production and a low fish toxic insecticide and/or acaricide containing them as an active ingredient | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ADORA1, CYP3A7, RDX | ACHE 132/4885PTGS2 2918/4885BCHE 974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.