SCHEMBL5708317

SCHEMBL5708317

CCOC(=O)Cc1cc(Cl)c(NC(=O)c2csc3ccccc23)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.43
MAPT P10636 3/20 0.43
RAB9A P51151 3/20 0.43
NPC1 O15118 2/20 0.43
TP53 P04637 2/20 0.43
NFKB1 P19838 2/20 0.43
HTT P42858 2/20 0.43
NFKB2 Q00653 2/20 0.43
RELA Q04206 2/20 0.43
HSD17B10 Q99714 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
NPSR1 Q6W5P4 1/20 0.43
MCOLN3 Q8TDD5 1/20 0.43
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL72217 0.91 MAPT (0.41) SMN1; SMN2MAPTRAB9ANPC1TP53
SCHEMBL70894 0.86 PIK3CA (0.46) SMN1; SMN2MAPTRAB9ANPC1TP53
SCHEMBL71893 0.85 HDAC3 (0.48) SMN1; SMN2MAPTRAB9ANPC1TP53
SCHEMBL73586 0.82 SMN1; SMN2 (0.45) SMN1; SMN2MAPTRAB9ANPC1TP53
SCHEMBL91757 0.81 HDAC3 (0.52) SMN1; SMN2MAPTRAB9ANPC1TP53
SCHEMBL71626 0.80 PKM (0.57) SMN1; SMN2MAPTNPC1MEN1KMT2A
SCHEMBL73880 0.80 MAOB (0.47) SMN1; SMN2MAPTRAB9ANPC1GAA
SCHEMBL3579447 0.79 ITGB1 (0.56) MAPTRAB9ANPC1MEN1KMT2A
SCHEMBL72586 0.77 MAPT (0.40) MAPTTP53KMT2AGAAALDH1A1
SCHEMBL72585 0.77 MAPT (0.40) MAPTTP53KMT2AGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
EP-1698611-A1 PROCESS FOR PRODUCING PHENYLACETIC ACID DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149606-A1 Process for producing phenylacetic acid derivative UGT1A4, VPS4B, CYP3A4 SMN1; SMN2 4325/4885MAPT 2970/4885RAB9A 3214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.