Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257480 | 0.87 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL7383813 | 0.85 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL24762008 | 0.85 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL24762895 | 0.85 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL28677877 | 0.85 | KDM4E (0.71) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL24762900 | 0.85 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL3239227 | 0.84 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL10767031 | 0.84 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL2627764 | 0.83 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL8575945 | 0.83 | MAPT (0.63) | ALDH1A1HPGDKDM4EGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119039221-A | Synthesis method of roflumilast | 沈阳药科大学 | 2024-11-29 | — | — | CN | claimed |
| CN-113717102-B | New preparation method of isoquinoline compound | 南通常佑药业科技有限公司 | 2024-07-26 | — | — | CN | claimed |
| CN-117825530-A | Method for detecting methyl tosylglycine | 中山奕安泰医药科技有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-108884047-B | Intermediates for the synthesis of aryl or heteroaryl substituted 5-hydroxy-1, 7-naphthyridine compounds and methods for their preparation | 沈阳三生制药有限责任公司 | 2022-03-08 | — | — | CN | claimed |
| CN-113717102-A | Novel preparation method of isoquinoline compound | 南通常佑药业科技有限公司 | 2021-11-30 | — | — | CN | claimed |
| EP-3275881-B1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO LTD (CN) | 2021-08-04 | — | — | EP | claimed |
| EP-3287456-B1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO LTD (CN) | 2020-08-26 | — | — | EP | claimed |
| CN-111499514-A | Preparation method of intermediate of roxasistat | 连云港润众制药有限公司 | 2020-08-07 | — | — | CN | claimed |
| CN-106146490-B | 5- hydroxyl -1,7- naphthyridine compounds, preparation method and its pharmaceutical applications replaced by aryloxy group or heteroaryloxy | 沈阳三生制药有限责任公司 | 2018-10-23 | — | — | CN | claimed |
| US-10100051-B2 | Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof | SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD. (CN) | 2018-10-16 | — | — | US | claimed |
| CN-108341777-A | Compound of isobioquin group and its application | 四川科伦博泰生物医药股份有限公司 | 2018-07-31 | — | — | CN | claimed |
| US-9994566-B2 | Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryl or heteroaryl, preparation method thereof and pharmaceutical use thereof | SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD. (CN) | 2018-06-12 | — | — | US | claimed |
| US-20180118738-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO., LTD. (CN) | 2018-05-03 | — | — | US | claimed |
| US-20180118739-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROARYLOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO., LTD. (CN) | 2018-05-03 | — | — | US | claimed |
| EP-3287456-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | Shenyang Sunshine Pharmaceutical Co., Ltd. (CN) | 2018-02-28 | — | — | EP | claimed |
| EP-3275881-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | Shenyang Sunshine Pharmaceutical Co., Ltd. (CN) | 2018-01-31 | — | — | EP | claimed |
| CN-106146490-A | 5-hydroxyl-1,7-naphthyridine compounds, its preparation method and the pharmaceutical applications thereof replaced by aryloxy group or heteroaryloxy | 沈阳三生制药有限责任公司 | 2016-11-23 | — | — | CN | claimed |
| EP-4739688-A2 | TRIAZOLO WRN INHIBITORS | Nimbus Wadjet, Inc. (US) | 2026-05-13 | — | — | EP | disclosed |
| US-4543422-A | ESTER INTERCHANGE OF A VINYL ESTER AND ALCOHOLATE OR PHENOLATE OF ALUMINUM, ZIRCONIUM, | ALLIED COLLOIDS LIMITED (GB) | 1985-09-24 | — | — | US | disclosed |
| EP-0118639-A1 | Synthesis of acrylic or methacrylic acid esters | Ciba Specialty Chemicals Water Treatments Limited (GB) | 1984-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118739-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROARYLOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | HIF1AN, EGLN3, EGLN2 | ALDH1A1 204/4885SMN1; SMN2 4001/4885HPGD 50/4885 |
| US-10100051-B2 | Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof | HIF1AN, EGLN3, EGLN2 | ALDH1A1 204/4885SMN1; SMN2 4001/4885HPGD 50/4885 |
| US-20180118738-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | HIF1AN, EGLN3, EGLN2 | ALDH1A1 119/4885SMN1; SMN2 3960/4885HPGD 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.